1603 CE
William Shakespeare makes a reference to opium in Othello

In his famous tragedy, Othello, Shakespeare makes a reference to opium: "Not poppy, nor mandragore, Nor all the drowsy syrups of the world, Shall ever medicine thee to that sweet sleep, Which thou ow'dst yesterday." The term "drowsy syrup" was used as a medical term for opium at the time.

Source: Martin, B. (1996). Opium: A History.

Drugs: Opium (morphine, heroin, opioids)
Regions: UK (England, Scotland, Wales, Northern Ireland)