Early 2000s
The term "Molly" becomes common in the U.S. to refer to powdered ecstasy

In the early 2000s, the term "Molly" becomes common in the U.S. to refer to powdered ecstasy/MDMA. The term implies that Molly is more pure than Ecstasy, and presumably comes from the word 'molecule'.

Source: MDMA Timeline (2015). The vaults of Erowid.