1916 - 1917 CE
Oxycodone is first synthesized in Germany

Oxycodone was first synthesized in Germany in 1916 as a semi-synthetic derivative of thebaine, an opiate alkaloid. It was first used clinically the following year under the brand name Eukodal.

Source: Rogers, K. (2016). Oxycodone. Encyclop├Ždia Britannica.

Drugs: Opium (morphine, heroin, opioids)
Regions: Germany