1901 CE
Luigi Bezzera invents the first commercial espresso machine

While looking for a method to quickly brew coffee directly into the cup, Luigi Bezzera invented single-shot espresso in the early 20th century. He made improvements to a steam-powered machine that had been patented in 1884 and some of the innovations he incorporated are still used in today's espresso machines.

Source: Pendergrast, M. (1999). Uncommon grounds. Basic Books.

Drugs: Caffeine (coffee, tea, cola, etc.)