c. 8850 - 4650 BCE
Coca chewing was in practice throughout wide area in the Americas

Lime containers (called poporos) made of shell have been found in burial sites at Las Vegas, Nevada and on the Santa Elena Penninsula of Ecuador. A pinch of lime was used as part of the coca leaf chewing process as it promotes the release of the leaf's psychoactive substances. People chewed coca leaves for their stimulant, medicinal, social and spiritual benefits.

Source: Stolberg, V. B. (2011). The use of coca. J Ethn Subst Abuse.

Drugs: Coca (cocaine)
Regions: USA (United States of America), Ecuador
Topics: Cultural factors (social, religious, ritual), Medicinal use of drugs