1560 CE
Bernardino de Sahagún makes reference to peyote in Historia general de las cosas de Nueva Espana

In what is believed to be the earliest historical reference to peyote, Bernardino de Sahagún mentions the psychoactive effects of the plant. He writes: "On him who drinks it or eats it, it takes effect like mushrooms. Also he sees many things which frighten one, or make one laugh. It affects him perhaps one day, perhaps two days, but likewise it abates." Bernardino de Sahagún also talks about the use of peyote in its native habitat, north of Mexico City, and how it affects the people who use it. Sahagún also writes about the use of psychedelic mushrooms by the Aztecs.

Source: Stewart, O. C. (1987). Peyote religion: A history (Vol. 181). University of Oklahoma Press.

Drugs: Peyote (mescaline), Psilocybin (mushrooms)
Regions: Spain, Mexico