1300 - 1521 CE
The Aztec people used psilocybian mushrooms during rituals and ceremonies

The Aztec people had a god of sacred psychoactive plants, the Prince of Flowers (or Xochipilli). Xochipilli was the divine patron of what the Aztecs called the ritual hallucinatory trance. The Aztecs used several hallucinogenic plants, including psilocybian mushrooms and Peyote, during ceremonies and rituals. Psilocybian mushrooms were served with honey or chocolate during some of their holiest events.

Source: Psilocybe Mushroom History (2011). Erowid.org.

Drugs: Peyote (mescaline), Psilocybin (mushrooms)
Regions: Mexico
Topics: Cultural factors (social, religious, ritual)