c. 5000 - 3000 BCE
Tobacco was first cultivated by people living in the Andes

Plant geneticists have established that tobacco's 'centre of origin,' the place where it was first cultivated, is located in the Andes Mountains of Peru and Ecuador. Tobacco was used for various medical, social and sacred purposes. Shamans smoked large amounts to induce visions and explore the spirit world. 

Source: Gately, I. (2001). Tobacco: A Cultural History. New York: Grove Press.

Drugs: Tobacco
Regions: Ecuador, Peru
Topics: Cultivation, production and trade, Cultural factors (social, religious, ritual)