Spanish missionary records from the 1600s and early 1700s mention the use of peyote by indigenous people in North America. These records indicate that peyote use was widespread across much of Northern Mexico.

Source: Stafford, P. G., & J. Bigwood (1992). Psychedelics Encyclopedia. Berkeley, CA: Ronin Pub.

Drugs:	Peyote (mescaline)
Regions:	Mexico

1600-1700 CESpanish missionary records from the 1600s and early 1700s indicate peyote use by indigenous people

1600-1700 CE
Spanish missionary records from the 1600s and early 1700s indicate peyote use by indigenous people