1893 CE
Methamphetamine is first synthesized

Methamphetamine, a variant of amphetamine, was first synthesized in Japan in 1893 by Nagayoshi Nagai from the chemical ephedrine.

Source: Origin and History (n.d.). Methamphetamine and other illicit drug education. University of Arizona.

Drugs: Stimulants (amphetamine, methamphetamine)
Regions: Japan