1554 CE
The first coffee houses are established in Constantinople

The first coffee houses are established in Constantinople under the reign of Suleiman the Great. While coffee drinking is the target of attacks by religious and political entities, it continues to spread and the number of coffee houses increases.

Source: Austin, G. A. et al. (1979). Perspectives on the history of psychoactive substance use. NIDA.

Drugs: Caffeine (coffee, tea, cola, etc.)
Regions: Turkey