1616 CE
Discovery of a tribe of American Indians who cultivated large tobacco fields in present-day Ontario

The French discover an Iroquoian branch of American Indians in present-day Ontario, Canada. Because of their large tobacco fields, they name them the Tobacco Nation, or Tionontati. After an attack by the Iroquois, the people remaining of the Tobacco Nation (along with refugees from another tribe) settled South West of Lake Superior. They were soon assimilated into one tribe, known as the Wyandot. In 1990 about 2,500 Wyandot still lived in the United States. 

Source: Tionontati (n.d.). Encyclopædia Britannica.